Dr. Jo first developed the technology behind ActivMend in 2012 for OcuMend. Over eight years, leading cosmetic dermatologists and surgeons used the product to reduce swelling and bruising. Four past presidents of the American Society for Dermatological Surgery endorsed OcuMend for its exceptional efficacy.
Allergan, a subsidiary of AbbVie, licensed the OcuMend product in 2019 following rigorous validation of its efficacy in reducing swelling and bruising, along with endorsements from leading physicians. Dr. Jo added the ‘Power 5’ ingredients to address swelling, pain and bruising in muscles, ligaments, tendons and bursae due to muscle pulls and sprains to create ActivMend.
Additionally, Dr. Polich was able to overcome a very skeptical US patent office by providing scientific clinical trials and signed affidavits from two past presidents of the American Society of Dermatological Surgeons, and the Department Chair of Orthopedic Surgery, Northwestern University.
SUMMARY
The study evaluated the recovery rates of 27 patients who used OcuMend after elective facial plastic surgery.
- 89% of patients recovered faster than average.
- 52% of patients recovered 7 days faster.
Joseph Aleshaki, DO1 and N. Josephine Polich, DC2 MS3
1Marian University College of Osteopathic Medicine, Indianapolis, IN 2National University of Health Sciences, Lombard, IL 3University of Virginia, Charlottesville, VA
The study induced bruising and compared the treatment effects of an inactive placebo gel patch with those of OcuMend. Evaluators assessed each bruise using a 10-point scale. The study induced bruising and compared the treatment effects of an inactive placebo gel patch with those of OcuMend. Evaluators assessed each bruise using a 10-point scale.In the study, OcuMend reduced bruising by 88% compared to the placebo, demonstrating significantly superior effectiveness in managing bruise severity.
OcuMend Double-blind trial data reported a Mean Bruise Score of 0.84 (Active) vs 6.91 (Placebo), representing a Cohen’s d effect size of 3.31 and a statistical significance of P = 0.0000005.
How Does Arnica Work?
Arnica works by selectively inhibiting the transcription factor NF-kappa B(2). NF-kappa B is a signaling pathway that regulates pro-inflammatory cell functions, playing a critical role in the inflammation process.
ActivvMend and OcuMend
OcuMend and ActivMend utilize the same proprietary hydrogel delivery technology and share core active ingredients (Arnica montana and Ledum palustre). ActivMend contains these actives at a higher concentration (1M potency) compared to OcuMend (50M potency), which is 50x more dilute. Evidence for OcuMend is considered directionally supportive and applicable to ActivMend.
